Chiral Lewis Acids-Controlled Synthesis. Enantioselective Synthesis of Both Diastereomers Including the α-Alkoxy-α-methyl-β-hydroxy Units

Abstract

Enantioselective synthesis of both diastereomers including the α-alkoxy-α-methyl-β-hydroxy units has been achieved by the chiral tin(II) Lewis acid-controlled aldol reactions of the silyl enolate derived from p-methoxyphenyl α-benzyloxypropionate (1) with aldehydes.