Thioureidoalkylphosphonates in the synthesis of 1-aminoalkylphosphonic acids. The Ptc-aminophosphonate method

Abstract

1-Aminoalkylphosphonic acids (AA P ) as structural analogues of protein amino acids (AA C ), are important inhibitors of amino acids metabolism. One of the three methods which have contributed to the development of the chemistry of 1-aminoalkylphosphonic acids is the Ptcaminoalkylphosphonate (Phenylthiocarbamoylaminoalkylphosphonate) method which allows a time saving synthesis of structurally diverse AA P of analytical purity on mmol-mol scale This review presents a comprehensive survey of this methodology development, with an emphasis on its scope and limitations.