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Efficient Synthesis of Functionalized 2-Pyridones from Malonyl Dichloride, Alkylamines and Dimethyl Acetylenedicarboxylate
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2007
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EngineeringMalonyl DichlorideNatural SciencesDiversity-oriented SynthesisPrimary AlkylaminesFunctionalized 2-PyridonesDimethyl 1-Alkyl-4-hydroxy-6-oxo-1,6-dihydropyridine-2,3-dicarboxylatesDimethyl AcetylenedicarboxylateOrganic ChemistryEfficient SynthesisChemistryStereoselective SynthesisPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
An efficient synthesis of dimethyl 1-alkyl-4-hydroxy-6-oxo-1,6-dihydropyridine-2,3-dicarboxylates is described. This involves a three-component reaction between primary alkylamines, malonyl dichloride, and dimethyl acetylenedicarboxylate.