Chiral Anisotropic Reagents for Determining the Absolute Configuration of Secondary Alcohols and Carboxylic Acids

Abstract

Based on the modified Mosher's method, we have developed several chiral anisotropic reagents. Together with a unique application of the modified Mosher's method to an enantiomeric mixture, utility of methoxy- (1- and 2-naphthyl) acetic acids (1NMA, 2NMA and other analogues) and phenylglycine methyl ester (PGME) in elucidation of the absolute configuration of secondary alcohols, amines, and carboxylic is summarized.