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In situ Formation of NOx and Br Anion for Aerobic Oxidation of Benzylic Alcohols without Transition Metal
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2010
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Chemical EngineeringVarious Benzylic AlcoholsEngineeringOxidation ResistanceBenzylic AlcoholsSustainable SynthesisOrganic ChemistryCatalysisTransition MetalChemistryBr AnionRedox ChemistryCatalytic ProcessSitu Generates NoxChemical KineticsCatalytic Synthesis
The reaction of KBrO3 and NH2OH˙HCl in situ generates NOx and Br anion, which combine with 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO) to construct a NO-activating dioxygen, Br-assisted, TEMPO-catalyzed aerobic oxidation of alcohols. Catalyzed by KBrO/NH2OH˙HCl/TEMPO, various benzylic alcohols can be oxidized quantitatively to their corresponding carbonyl compounds under mild conditions. The easy handling and simple product separation make the process an attractive candidate for the oxidation of alcohols.