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Microwave-Assisted and Yb(OTf)3-Promoted One-Pot Multicomponent Synthesis of Substituted Quinolines in Ionic Liquid
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2011
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Ionic LiquidChemical EngineeringEngineering2,4-Disubstituted QuinolinesCatalytic SynthesisOrganic ChemistryMicrowave IrradiationCatalysisChemistrySynthesis MethodSubstituted QuinolinesSynthetic ChemistryEnantioselective SynthesisMicrowave Synthesis
A straightforward and efficient method has been developed for the synthesis of quinolines by Yb(OTf)3 catalyzed three-component reaction of aldehydes, alkynes, and amines under microwave irradiation in ionic liquid. A series of 2,4-disubstituted quinolines was synthesized in excellent yield (69-93%) under mild reaction condition and the catalyst was recycled for four cycles.