Concepedia

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating <i>Mycobacterium tuberculosis</i>

Landys Lopez Quezada, Kelin Li, Stacey L. McDonald, Quyen Thi Nguyen, Andrew J. Perkowski, Cameron W. Pharr, Ben Gold, Julia Roberts, Kathrine McAulay, Kohta Saito,

ACS Infectious Diseases · 2019 · 18 citations · 68 references

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Abstract

could be killed both by released pyrithione and by the parent β-lactam. Thus, the antimycobacterial activity of pyrithione-containing cephalosporins arises from two mechanisms that kill mycobacteria in different metabolic states.

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