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An Expedient and Efficient Method for the Cleavage of Dithioacetals to the Corresponding Carbonyl Compounds Using Organic Ammonium Tribromide (OATB)
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2001
Year
Chemical EngineeringEngineeringHeterocyclicEfficient MethodTetrabutylammonium TribromideOrganic ChemistryKetones 1ChemistryOrganic Ammonium TribromidesDerivative (Chemistry)Synthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A variety of dithioacetals of aldehydes or ketones 1 can be easily cleaved into the parent carbonyl compounds 2 at 0-5 °C in very high yields by employing organic ammonium tribromides such as cetyltrimethyl-ammonium tribromide (CetTMATB) or tetrabutylammonium tribromide (TBATB) in dichloromethane.