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Bismuth(III)-Catalyzed Rapid Synthesis of 2,3-Disubstituted Quinoxalines in Water
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2008
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High YieldsEngineeringCatalytic AmountOrganic Chemistry2,3-Disubstituted QuinoxalinesCatalysisStereoselective SynthesisChemistryHeterocycle ChemistryPharmacologySynthetic ChemistryEnantioselective Synthesis
A variety of 2,3-disubstituted quinoxalines are readily prepared in high yields under extremely mild conditions by cyclocondensation of arene-1,2-diamines with 1,2-dicarbonyls using a catalytic amount of bismuth(III) triflate. The reactions of 2,3-diaminopyridine with 1,2-dicarbonyls produce pyrido[2,3-b]pyrazine derivatives under similar conditions.