Synthesis of β,γ-Unsaturated Lactams via a Magnesium Iodide Promoted Ring Expansion of Secondary Methylenecyclopropyl Amides

Abstract

A novel and efficient route to exo-beta,gamma-unsaturated lactams from substituted and non-substituted secondary methylenecyclopropyl amides is reported. Subsequent modification of the resulting exo-beta,gamma-unsaturated lactams provides access to several pharmaceutically relevant scaffolds. [reaction: see text].