α-Bromination of β-Enamino Compounds Using K-10

Abstract

A series of α-bromo 3-amino-5,5-dimethylcyclohex-2-en-1-ones 2a-g and α-bromo β-enamino compounds 4a, b have been conveniently prepared using NBS supported on montmorillonite (K-10). Other reaction conditions such as di-tert-butyl peroxide/NBS/CCl4, and Br2/CH2Cl2 were also studied for 3-amino-5,5-dimethylcyclohex-2-en-1-ones 1b, e, g resulting in a mixture of mono and di-brominated compounds 5b, f, g and 6b, e, g.