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A Practical Method for the Reformatsky Reaction of Aldehydes
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2000
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Chemical EngineeringEngineeringBf3 · Oet2Chemical TransformationReformatsky ReactionOrganic ChemistryCatalysisChemistrySynthesis MethodAliphatic Aldehydes
Reformatsky reaction of aliphatic aldehydes has been performed successfully by the addition of BF3 · OEt2 to a stirred suspension of aldehyde, bromo ester and Zn dust in aqueous THF. For aromatic aldehydes, addition of benzoyl peroxide is also required to effect the reaction.