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An Efficient New Procedure for the One-Pot Conversion of Aldehydes into the Corresponding Nitriles
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2007
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Chemical EngineeringNovel OrganocatalystsEngineeringChemical TransformationVarious AldehydesOrganic ChemistryCatalysisChemistryOne-pot ConversionEfficient New ProcedureCorresponding NitrilesSynthesis MethodAldoxime IntermediatesEnantioselective Synthesis
A new and efficient procedure for the one-pot conversion of various aldehydes into the corresponding nitriles under mild reaction conditions has been developed. The ethyl dichlorophosphate/DBU-mediated dehydration of aldoxime intermediates was utilized as a key operation to effect the transformation.