Publication | Closed Access
A New Strategy for the Synthesis of Furan-3,4-dicarboxylic Acid
16
Citations
0
References
2002
Year
Dimethylmaleic AnhydrideEngineeringBiochemistryFacile RouteNatural SciencesMaleic AnhydrideOrganic ChemistryChemistryNew StrategyNatural Product SynthesisDerivative (Chemistry)Synthetic ChemistryBiomolecular Engineering
A facile route to furan-3,4-dicarboxylic acid is described. Dimethylmaleic anhydride (1) on NBS-bromination followed by aqueous KOH treatment gave bis(hydroxymethyl)maleic anhydride (3), which on intramolecular Mitsunobu ring closure followed by esterification and DDQ-oxidation furnished the desired esters of furan-3,4-dicarboxylic acid 7a/b.