Letters in Organic Chemistry · 2009 · 16 citations · 0 references
PharmacyMedicinal ChemistryDrug DiscoveryMolecular VirologySynthetic Medicinal ChemistryAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyAntiviral TherapyNucleic Acid SynthesisNucleobase ChemistryH-phosphonate SynthesisNon-nucleoside AntiviralsNon-nucleoside Reverse Transcriptase InhibitorsNucleoside Analog SynthesisNucleoside AnalogsNucleoside Analogue AntiviralsNucleoside Reverse Transcriptase InhibitorsNucleotide Analogue Synthesis
Crystalline ammonium (9H-fluoren-9-yl)methyl H-phosphonate was prepared by a new, simple method and it was used as the reagent of choice for the introduction of an H-phosphonate monoester functionality into non-lipophilic anti-HIV nucleoside analogues. Keywords: H-phosphonates, phosphonylating agents, nucleoside analogues, nucleoside H-phosphonates, protecting groups, β-elimination