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A New, Efficient Entry to Non-Lipophilic H-Phosphonate Monoesters – Preparation of Anti-HIV Nucleotide Analogues
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2009
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Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryH-phosphonate Monoester FunctionalityBiochemistrySimple MethodNatural SciencesMedicineNon-lipophilic H-phosphonate MonoestersAntiviral Drug DevelopmentCrystalline AmmoniumOrganic ChemistryAntiviral DrugHivAnti-hiv Nucleotide AnaloguesPharmacologyAntiviral CompoundEfficient Entry
Crystalline ammonium (9H-fluoren-9-yl)methyl H-phosphonate was prepared by a new, simple method and it was used as the reagent of choice for the introduction of an H-phosphonate monoester functionality into non-lipophilic anti-HIV nucleoside analogues. Keywords: H-phosphonates, phosphonylating agents, nucleoside analogues, nucleoside H-phosphonates, protecting groups, β-elimination