Organic Letters · 2019 · 57 citations · 34 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MechanismsHeterocycle SynthesisOrganic SynthesisAromatic Nucleophilic SubstitutionC - H Bond FunctionalizationCatalytic Reaction MechanismsHeterocycle Functionalization
A Pd-catalyzed intramolecular C–H arylation of nitroarenes has been developed. Nitroarenes bearing tethered aryl groups at the ortho-position can be readily prepared in one step from 2-halonitroarenes by a nucleophilic aromatic substitution (SNAr). Under Pd/BrettPhos catalysis, activations of the C–NO2 bond as well as the C–H bond on arenes generated the corresponding biaryl linkage in moderate to excellent yields.
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