The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

Abstract

QA modulated intracellular Ca²⁺ homeostasis, enhancing glucose-stimulated insulin secretion in both INS-1E cells and mouse islets. By increasing mitochondrial Ca²⁺ , QA activated the coordinated stimulation of oxidative metabolism, mitochondrial ATP synthase-dependent respiration, and therefore insulin secretion. Bioactive agents raising mitochondrial Ca²⁺ in pancreatic beta-cells could be used to treat diabetes.