Factors Associated With Age Disparities Among Cancer Clinical Trial Participants

Ethan B. Ludmir, W. Ian P. Mainwaring, Timothy A. Lin, Austin B. Miller, Amit Jethanandani, Andres F. Espinoza, Jacob Mandel, Steven H. Lin, Benjamin D. Smith, Grace L. Smith,

JAMA Oncology · 2019 · 212 citations · 11 references

DOIFull text

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Abstract

Age disparities between trial participants and the incident disease population are pervasive across trials and appear to be increasing over time. Industry sponsorship of trials is associated with heightened age imbalances among trial participants. With an increasing role of industry funding among cancer trials, efforts to understand and address age disparities are necessary to ensure generalizability of trial results as well as equity in trial access.

References

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