Versatile “on–off” biosensing of thrombin and miRNA based on Ag(<scp>i</scp>) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

Abstract

A novel biosensing platform based on Ag(<sc>i</sc>) ion-enhanced or Ag nanoclusters (NCs)-quenched electrochemiluminescence (ECL) of CdSe quantum dots (QDs) was designed for versatile “on–off” assays of thrombin (TB) and miRNA.