Presymptomatic spinal cord pathology in <i>c9orf72</i> mutation carriers: A longitudinal neuroimaging study

Abstract

Cervical SC imaging detects WM atrophy exclusively in C9⁺ subjects older than 40 years, and progressive CST FA reductions can be identified on 18-month follow-up. Cervical SC magnetic resonance imaging readily captures presymptomatic pathological changes and disease propagation in c9orf72-associated conditions. ANN NEUROL 2019;86:158-167.