Metal-free visible-light induced cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones and diselenides: access to 5-hydroxy-3-selenyl-4a,8a-dihydro-2<i>H</i>-chromen-6(5<i>H</i>)-ones

Abstract

A simple and efficient Se-radical triggered cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones to the product of <bold>3</bold> has been developed. The compounds <bold>3e</bold> and <bold>3q</bold> showed potent cancer cell-growth inhibition activities.