Concepedia

Osteoclast‐Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss

Sacha Flammier, Olivier Peyruchaud, Fanny Bourguillault, F. Duboeuf, J. Davignon, Derek D. Norman, Sylvie Isaac, Hubert Marotte, Gábor Tigyi, Irma Machuca‐Gayet,

Arthritis & Rheumatology · 2019 · 21 citations · 38 references

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Abstract

Our results identify ATX as a novel OC factor that specifically controls inflammation-induced bone erosions and systemic bone loss. Therefore, ATX inhibition offers a novel therapeutic approach for potentially preventing bone erosion in patients with RA.

References

38

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

Jeanne Keffer, Lesley Probert, Haris Cazlaris et al. · The EMBO Journal · 1991 · 1.6K citations · Full text

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Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

Takashi Nakamura, Yuuki Imai, Takahiro Μatsumoto et al. · Cell · 2007 · 980 citations · Full text

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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

Makiko Umezu‐Goto, Yasuhiro Kishi, Akitsu Taira et al. · The Journal of Cell Biology · 2002 · 918 citations · Full text

TRANCE/RANKL Knockout Mice Are Protected from Bone Erosion in a Serum Transfer Model of Arthritis

Allison R. Pettit, Hong Ji, D. von Stechow et al. · American Journal Of Pathology · 2001 · 803 citations

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An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis

Andrew K. Brown, Philip G. Conaghan, Z Karim et al. · Arthritis & Rheumatism · 2008 · 777 citations