Concepedia

Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction

G. Lakshma Reddy, Mohd Ishaq Dar, Abhinandan D. Hudwekar, Priya Mahajan, Amit Nargotra, Adil Manzoor Baba, Utpal Nandi, Priya Wazir, Gurdarshan Singh, Ram A. Vishwakarma,

Bioorganic Chemistry · 2019 · 22 citations · 20 references

DOI

Concepts

References

20

Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy

Richard A. Friesner, Jay L. Banks, Robert B. Murphy et al. · Journal of Medicinal Chemistry · 2004 · 9.9K citations

, , +17

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

G. Madhavi Sastry, Matvey Adzhigirey, Tyler Day et al. · Journal of Computer-Aided Molecular Design · 2013 · 6K citations

, , +14

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

N.K. Terrett, Andrew Bell, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 606 citations

, , +12

Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells

Robert B. Moreland, Irwin Goldstein, Abdulmaged M. Traish · Life Sciences · 1998 · 206 citations

, , +10

Multiple Conformations of Phosphodiesterase-5

Huanchen Wang, Yudong Liu, Qing Huai et al. · Journal of Biological Chemistry · 2006 · 161 citations · Full text

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