Impact of Growth Hormone Therapy on Adult Height in Patients with <b><i>PTPN11</i></b> Mutations Related to Noonan Syndrome

Abstract

This study supports the advantage of rhGH therapy on adult height in PTPN11+ patients. In comparison, PTPN11- patients showed a poor response to rhGH. However, this PTPN11- group was small, preventing an adequate comparison among different genotypes and no guarantee of response to therapy in genes besides PTPN11.