LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival

Abstract

OBJECTIVE: To elucidate the role and prognostic significance of lymphocyte activation-gene-3 (LAG-3) in soft tissue sarcoma (STS). METHODS: T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model. RESULTS: T cells. CONCLUSIONS: LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS.