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Estrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer

DOIFull Paper Access

33

Citations

37

References

2019

Year

Yongmei Shen, Jiasong Cao, Zhixian Liang, Qimei Lin, Jianxi Wang, Yang Xu, Ran Zhang, Jiaojiao Zong, Xiaoling Du, Yanfei Peng,
Cell Communication and Signaling

Abstract

Our results implicated CD49f+/ERα + prostate cancer cells associated with basal stem-like and EMT features, named EMT-PCBSLCs, in heightened potential for promoting metastasis. NOTCH1 was regulated by E2 in CD49f<sup>Hi</sup> EMT-PCBSLCs. These results contribute to insights into the metastatic mechanisms of EMT-PCBSLCs in PCa.

References

YearCitations

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