A new fusicoccane diterpene and a new polyene from the plant endophytic fungus <i>Talaromyces pinophilus</i> and their antimicrobial activities

Abstract

A new fusicoccane diterpene, pinophicin A (<b>1)</b>, and a new polyene, pinophol A (<b>2</b>), were isolated from the plant endophytic fungus <i>Talaromyces pinophilus</i> obtained from the aerial parts of <i>Salvia miltiorrhiza</i>. The structures and relative configurations of <b>1</b>-<b>2</b> were determined by the analysis of extensive spectroscopic data, chemical method, and comparison with known compounds. Compound <b>2</b> exhibited weak antibacterial activity against <i>Bacterium paratyphosum</i> B with an MIC value of 50 μg/mL.