Direct Amination of Arenes with Azodicarboxylates Catalyzed by Bisulfate Salt/HFIP Association

Abstract

A mild and efficient amination of arenes with azodicarboxylates using potassium bisulfate (KHSO₄) as the catalyst in 1,1,1,3,3,3-hexafluoro-2-propanol has been developed. This protocol allowed the amination of a broad range of arenes leading to corresponding hydrazides in good to excellent yields.