Decarboxylative [4+2] annulation of arylglyoxylic acids with internal alkynes using the anodic ruthenium catalysis

Abstract

A new electrochemical decarboxylative [4+2] annulation of arylglyoxylic acids with internal alkynes involving C-H functionalization by means of a cooperative anode and ruthenium catalysis is presented. This reaction represents a mechanistically novel strategy as an ideal supplement to the decarboxylative [4+2] annulation methodology by employing an electrooxidative process to avoid the use of an additional external oxidizing reagent and utilizing H₂O as the carboxyl oxygen atom source to be engaged in the synthesis of 1H-isochromen-1-ones.