Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

Life Sciences, Immunology, Molecular Biology +14

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al. · Nature · 2015 · 3.7K citations

Life Sciences, Cell Biology, Immunology +13

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

Theodore J. Iwashyna, E. Wesley Ely, Dylan M. Smith et al. · JAMA · 2010 · 2.6K citations

Medicine, Neurology, Psychiatry +16

Immunodesign of experimental sepsis by cecal ligation and puncture

Daniel Rittirsch, Markus Huber‐Lang, Michael A. Flierl et al. · Nature Protocols · 2008 · 2.2K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +12