A new oleanane type pentacyclic triterpenoid saponin from the husks of <i>xanthoceras sorbifolium</i> bunge and its neuroprotection on PC12 cells injury induced by Aβ_25-35

Abstract

A new triterpenoid saponin (1), 3-O-[β-D-glucopyranosyl(1→6)]-(2′-angeloyl)-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl(1→6)[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-21-O-acetyl-16-deoxybarringtogenol C, together with four known saponins (2 ∼ 5) were isolated from the husks of Xanthoceras sorbifolium Bunge. Their structures were characterized by HR-ESI-MS, 1D-NMR, 2D-NMR spectra and chemical methods. Compound 1 exhibited excellent neuroprotection on PC12 cells injury induced by Aβ25-35 at the doses of 150 μmol/L and 200 μmol/L. The cell viabilities were (76.18 ± 2.09) % and (76.02 ± 3.20) %, respectively.