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The HOPE (Heart Outcomes Prevention Evaluation) Study: The design of a large, simple randomized trial of an angiotensin converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events

Non-pharmacological InterventionPreventive MedicineCardiovascular DiseaseAntihypertensive TherapyClinical TrialsOutcomes ResearchSimple Randomized TrialRandomized Controlled TrialPharmacotherapyPreventive CardiologyMedicineCardiovascular EventsHigh Risk