A new polyacetylene and other constituents with anti-inflammatory activity from <i>Artemisia halodendron</i>

Abstract

A new polyacetylene, (3 <i>R</i>,8<i>S</i>)-heptadeca-1,16-dien-4,6-diyne-3,8-diol (<b>1</b>), together with 10 known compounds (<b>2</b>-<b>11</b>) were isolated from an ethanol extract of <i>Artemisia halodendron</i> Turcz. ex Bess. (Asteraceae). The chemical structures of these compounds were elucidated by NMR and HR-ESI-MS analysis, and by comparing these results with data reported in literatures. Compounds <b>1</b>-<b>11</b> were evaluated for their inhibitory activity against NO, TNF-α and IL-6 production. Compounds <b>1</b>-<b>11</b> significantly inhibited the levels of NO, TNF-α and IL-6 in LPS-induced RAW264.7 cells in a dose-dependent manner, with IC₅₀ values ranging from 15.12 to 66.97 µM.