Concepedia

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial

Adam L. Boxer, Irfan Qureshi, Michael K. Ahlijanian, Michael Grundman, Lawrence I. Golbe, Irene Litvan, Lawrence S. Honig, Paul Tuite, Nikolaus R. McFarland, Padraig O’Suilleabhain,

The Lancet Neurology · 2019 · 141 citations · 27 references

DOI

Concepts

References

27

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

David W. Sanders, Sarah K. Kaufman, Sarah L. DeVos et al. · Neuron · 2014 · 1K citations · Full text

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

Florence Clavaguera, Hiroyasu Akatsu, Graham Fraser et al. · Proceedings of the National Academy of Sciences · 2013 · 762 citations · Full text

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A clinical rating scale for progressive supranuclear palsy

Lawrence I. Golbe, Pamela Ohman‐Strickland · Brain · 2007 · 613 citations · Full text

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Tau Kinetics in Neurons and the Human Central Nervous System

Chihiro Sato, Nicolas R. Barthélemy, Kwasi G. Mawuenyega et al. · Neuron · 2018 · 596 citations · Full text

, , +14

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

Kiran Yanamandra, Najla Kfoury, Hong Jiang et al. · Neuron · 2013 · 582 citations · Full text

, , +16