Potent and selective <i>in vitro</i> and <i>in vivo</i> antiproliferative effects of metal–organic trefoil knots

Abstract

the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development.