Late glucocorticoid receptor antagonism changes the outcome of adult life stress

Jinlan Ding, Marcia Santos da Silva, Jolanthe Lingeman, Chen Xinzhao, Yuxiu Shi, Fang Han, Onno C. Meijer

Psychoneuroendocrinology · 2019 · 25 citations · 59 references

DOIFull text

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Abstract

The effects of RU486 applied 1 week after stress and measured 4 days after treatment demonstrate that in the state of post-SPS the GR-dependence of homeostatic processes has changed. This suggests that GR-mediated processes are part of allostatic regulation after adult stress. The normalization of a number of SPS-effects after RU486 treatment reinforces the potential of targeting GR for treatment of stress-related psychopathologies.

References

59