Rhodium‐Catalyzed Asymmetric [2+2+2] Cycloaddition Reactions of 1,6‐Enynes and Oxabenzonorbornadienes

Abstract

Abstract The asymmetric [2+2+2] cycloaddition reactions of 1,6‐enynes and oxabenzonorbornadienes was accomplished by using the complex of [Rh(COD) 2 ]BF 4 and ( R )‐Xyl‐P‐Phos as chiral catalyst. A range of 1,6‐enynes and oxabenzonorbornadienes were well tolerated in the cycloaddition reaction, which afforded various polycyclic products with asymmetric quaternary carbon centers generally in excellent enantioselectivities. magnified image