T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T‐cell costimulator

Abstract

BACKGROUND: Atopic dermatitis (AD) is a heterogeneous disease, characterized by excess T helper (Th) 22 activation in Asian AD. Inducible T-cell costimulator (ICOS) is crucial for T-cell activation and differentiation. However, the role of ICOS in AD and its effect on Th22 cells remain unclear. OBJECTIVES: To gain a better understanding of the role of ICOS and ICOS ligand (ICOSL) in the pathogenesis of Asian AD and its underlying mechanisms. METHODS: We quantified ICOS and ICOSL expression in Han Chinese patients with AD and healthy controls (HC). Then, we assessed the proliferation and the production of the Th22 chemokines CCR4 and CCR10 by ICOSL-stimulated AD peripheral blood mononuclear cells (PBMCs) as well as their effects on keratinocyte filaggrin production. Finally, we explored the link between ICOS-expressing Th22 cells and disease activity and IgE levels in our patients with AD. RESULTS: cells in lesional skin were all markedly increased. CONCLUSIONS: B cells are potential clinical biomarkers of disease activity in Han Chinese patients with AD. ICOS- and ICOSL-targeted treatment approaches may benefit Han Chinese patients with AD.