A novel label-free terbium(<scp>iii</scp>)-aptamer based aptasensor for ultrasensitive and highly specific detection of acute lymphoma leukemia cells

Abstract

cells per ml, while the detection limit was 5 cells per ml of the binding buffer. Clinical samples were collected from 100 cases, and the specificity and positive rates detected by this method were up to 94% and 90%, respectively. Therefore, a single-stranded DNA-sensitized terbium(iii) luminescence method diagnostic was developed which is rapid, sensitive, and economical and can be used for diagnosis of various types of leukemia at the early stage.