68Ga-NODAGA-exendin-4 PET/CT for the localization of insulinomas

Abstract

Insulinomas are usually small, single benign tumors. Precise preoperative anatomical localization of the tumor is essential. Imaging techniques like CT, MRI as well as somatostatin receptor (SSTR) imaging have limited sensitivity (1). The stable glucagon like peptide-1 (GLP-1) analog exendin specifically binds the GLP-1 receptor (GLP-1R), which is markedly overexpressed in insulinomas. We propose 68Ga-NODAGA-exendin-4 PET/CT as a promising new method for improved localization of insulinomas.