In Vitro and in Vivo Degradation Behavior and Biocompatibility Evaluation of Microarc Oxidation-Fluoridated Hydroxyapatite-Coated Mg–Zn–Zr–Sr Alloy for Bone Application

Abstract

Magnesium and its alloys are biodegradable materials with great potential for biomedical development; however, their high rate of degradation in biological environments limits the widespread application of these materials. In order to improve the corrosion resistance of magnesium alloy, a functional calcium phosphate coating was prepared on Mg-3Zn-0.5Zr-0.5Sr alloy by microarc oxidation (MAO) combined with chemical deposition of fluoridated hydroxyapatite (FHA). A dense calcium-phosphorus coating 6 μm thick composed of needle-shaped fluoridated hydroxyapatite formed on the surface of the MAO layer. The MAO-FHA coating exhibited good mineralization ability to induce hydroxyapatite deposition on its surface during degradation testing in simulated bodily fluids.