Palladium Catalyzed C−H Olefination of Indolizines at the 1‐Position with Molecular Oxygen as the Terminal Oxidant

Abstract

Abstract A regioselective C1‐olefination of indolizines enabled by Pd II ‐catalyzed non‐directed C−H activation has been developed. Molecular oxygen is employed in this protocol as the terminal oxidant and with a catalytic amount Cu II salt as the co‐oxidant. A broad range of simple and highly fused indolizine substrates were compatible with the reaction conditions, enabling the straightforward synthesis of valuable C1‐substituted indolizine derivatives.