Base‐Catalyzed 1,6‐Hydrophosphonylation of <i>p</i>‐Quinone Methides with Diphenylphosphane Oxide/Phosphites

Abstract

A novel base‐catalyzed 1,6‐conjugated addition of p ‐QMs with diphenylphosphane oxide/phosphites has been developed. This reaction provides a highly efficient strategy for the construction of diarylmethyl phosphonate compounds in moderate to excellent yields with a broad substrate scope and good functional group tolerance under mild and metal‐free conditions. Moreover, the reaction can be carried out on a gram scale, which opens up the possibility for practical applications.