Cyanidin 3-Rutinoside, an Anthocyanin Pigment of <i>Schisandra chinensis</i> Baill, Inhibits Allergic Inflammation

Abstract

The occurrence of allergy-mediated inflammatory diseases such as asthma and atopic dermatitis have increased, but comprehensive treatment remains difficult. Previous studies have shown that <i>Schisandra chinensis</i> Baill has antioxidant, antidiabetic, and antitumorigenic effects. Cyanidin 3-rutinoside (CR) is the major anthocyanin pigment of <i>S. chinensis</i>. However, the biological effects of CR have been rarely studied to date. Therefore, the aim of this study was to investigate the regulatory effects of CR on phorbol-12-myristate-13-acetate (PMA)/A23187-induced allergic inflammation <i>in vitro</i>. CR inhibited the secretion of inflammatory cytokines such as interleukin-6 and tumor necrosis factor-<i>α</i>, and it also suppressed the phosphorylation of nuclear factor-kappa B. These results show that CR ameliorated PMA/A23187-induced allergic inflammation via the suppression of inflammatory cytokines in HMC-1 cells. Therefore, CR has potential as a therapeutic agent for allergic diseases.