Site‐Selective, Remote sp³ C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis

Abstract

A photoinduced carboxylation of alkyl halides with CO₂ at remote sp³ C-H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.