Concepedia

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

Malina A. Bakowski, Roohollah Kazem Shiroodi, Renhe Liu, Jason Olejniczak, Baiyuan Yang, Kerstin Gagaring, Hui Guo, Pamela M. White, Laura Chappell, Alain Debec,

Science Translational Medicine · 2019 · 45 citations · 53 references

DOI

Concepts

Abstract

(a safety concern in endemic areas). The favorable efficacy and in vitro safety profiles of CBR490 and CBR417 further support these as clinical candidates for treatment of filarial infections.

References

53

A new mathematical model for relative quantification in real-time RT-PCR

Michael W. Pfaffl · Nucleic Acids Research · 2001 · 34.9K citations · Full text

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Primer3—new capabilities and interfaces

Andreas Untergasser, Ioana Cutcutache, Triinu Kõressaar et al. · Nucleic Acids Research · 2012 · 9.8K citations · Full text

, , +9

Enhancements and modifications of primer design program Primer3

Triinu Kõressaar, Maido Remm · Bioinformatics · 2007 · 2.7K citations · Full text

, , +11

The Wolbachia genome of Brugia malayi: Endosymbiont evolution within a human pathogenic \nnematode

Jeremy M. Foster, Mehul B. Ganatra, Ibrahim H. Kamal et al. · eScholarship (California Digital Library) · 2005 · 642 citations

, , +13

Phylogeny of Wolbachia in filarial nematodes

Claudio Bandi, Tim Anderson, C. Genchi et al. · Proceedings of the Royal Society B Biological Sciences · 1998 · 595 citations

, , +8