Cell Cycle · 2019 · 15 citations · 30 references
Life SciencesCell BiologyMolecular BiologyCell CycleCell DivisionDna ReplicationDna DamageDna Damage SignalingDna Strand BreaksMitosisMitotic ExitAtm-mediated Checkpoint SignalingChk1 SignalingDna Damage Checkpoint ActivationDna Damage Checkpoint KinasesDna Damage Checkpoint SignalingGreatwall Kinase SignalingMitotic SlippageProtein Dephosphorylation
phase. Therefore, to adapt to severe DNA damage, the activated Greatwall/ENSA signaling pathway was repressed by ATM/Chk1/2, even in mitotic cells. Activation of the PP2A-B55 holoenzyme complex induced the dephosphorylation of Plk1 and Cdk1, and finally, mitotic slippage occurred without normal chromosome segregation and cytokinesis.
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Andrew Burgess, Suzanne Vigneron, Estelle Brioudes et al. · Proceedings of the National Academy of Sciences · 2010 · 691 citations
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
Beth Furnari, Paul Russell · Science · 1997 · 541 citations
Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2Α That Is Essential for Mitosis
Satoru Mochida, Sarah Maslen, Mark Skehel et al. · Science · 2010 · 437 citations · Full text