Nanomedicine · 2018 · 44 citations · 36 references
PharmacyOncologyPharmacologyApoptosisChemotherapyDrug DeliveryCancer NanomedicineCytotoxic ChemotherapyLipid-based NanoparticlesNanocarriers For TherapeuticsNanomedicineNanoparticle DesignAnticancer ActivityAnticancer ChemotherapyAnticancer Drug LoadingAntineoplastic Drug TherapyCancer NanotherapyIntrinsic Apoptosis PathwayLipid-based Nanoparticle FormulationNanoparticle-based Chemotherapy
AIM: To investigate the enhancement of anticancer activity of thymoquinone (TQ) by the use of nanostructured lipid carrier (NLC) in 4T1 tumor-bearing female BALB/c mice. MATERIAL & METHODS: TQ was incorporated into NLC (TQNLC) by using high pressure homogenization. TQNLC and TQ were orally administered to the mice. RESULTS & CONCLUSION: TQNLC and TQ are potential chemotherapeutic drugs as they exhibited anticancer activity. The use of NLC as a carrier has enhanced the therapeutic property of TQ by increasing the survival rate of mice. The antimetastasis effect of TQNLC and TQ to the lungs was evidence by downregulation of MMP-2. TQNLC and TQ induced apoptosis via modulation of Bcl-2 and caspase-8 in the intrinsic apoptotic pathway.
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Rebecca L. Siegel, Deepa Naishadham, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2012 · 10.7K citations · Full text
Drug Solubility: Importance and Enhancement Techniques
Ketan T. Savjani, Anuradha Gajjar, Jignasa Savjani · ISRN Pharmaceutics · 2012 · 2K citations · Full text