An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes<i>S100A3</i>and<i>S100A13</i>

Abstract

Our data demonstrate that digenic inheritance of mutations in <i>S100A3</i> and <i>S100A13</i> underlie the pathophysiology of pulmonary fibrosis associated with a significant reduction of both proteins, which suggests a calcium-dependent therapeutic approach for management of the disease.