Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

Merja Lakso, José G. Pichel, James Gorman et al. · Proceedings of the National Academy of Sciences · 1996 · 1.1K citations · Full text

Transgenic Mouse Models, Genetics, Molecular Genetics +18

Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat

Timothy J. Ness, G. F. Gebhart · Brain Research · 1988 · 661 citations

Functional Gastrointestinal Disorder, Health Sciences, Gastrointestinal Pharmacology +13

Intradermal Injection of Capsaicin in Humans Produces Degeneration and Subsequent Reinnervation of Epidermal Nerve Fibers: Correlation with Sensory Function

Donald A. Simone, Maria Nolano, Timothy Johnson et al. · Journal of Neuroscience · 1998 · 366 citations · Full text

Peripheral Nerve Injury, Intradermal Injection, Pain Medicine +22

Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice

Stuart M. Brierley, R. Carter W. Jones, Gerald F. Gebhart et al. · Gastroenterology · 2004 · 309 citations

Colonic Stimuli, Physiology, Gastroenterology +6

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

Samuel Bertin, Yukari Aoki‐Nonaka, Petrus R. de Jong et al. · Nature Immunology · 2014 · 254 citations · Full text

Proinflammatory Properties, Signal Transduction, T-regulatory Cell +9